Rapamycin maintains the primordial follicle pool and protects ovarian reserve against cyclophosphamide-induced damage

Any abnormal activation of primordial follicles and subsequent depletion can irreversibly diminish the ovarian reserve, which is one of the major chemotherapy-induced adverse effects in young patients with cancer. Herein, we investigated the effects of rapamycin on the activation and development of...

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Bibliographic Details
Published in:The Journal of Reproduction and Development
Main Authors: Xiuying CHEN, Zhijing TANG, Haiyun GUAN, Hexia XIA, Chao GU, Yan XU, Bin LI, Wei ZHANG
Format: Article
Language:English
Published: The Society for Reproduction and Development 2022-06-01
Subjects:
cyclophosphamide
ovarian reserve
primordial follicle
rapamycin
Online Access:https://www.jstage.jst.go.jp/article/jrd/68/4/68_2022-001/_pdf/-char/en

Internet

https://www.jstage.jst.go.jp/article/jrd/68/4/68_2022-001/_pdf/-char/en

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