Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells

Summary: Cancer cells often acquire resistance to cell death programs induced by loss of integrin-mediated attachment to extracellular matrix (ECM). Given that adaptation to ECM-detached conditions can facilitate tumor progression and metastasis, there is significant interest in effective eliminatio...

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Bibliographic Details

Published in:	iScience
Main Authors:	Jianping He, Abigail M. Abikoye, Brett P. McLaughlin, Ryan S. Middleton, Ryan Sheldon, Russell G. Jones, Zachary T. Schafer
Format:	Article
Language:	English
Published:	Elsevier 2023-06-01
Subjects:	Cell biology Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223009045