Why methylation is not a marker predictive of response to hypomethylating agents

The azanucleotides azacitidine and decitabine have been shown to induce hematologic response and prolong survival in higher-risk myelodysplastic syndromes. They are inhibitors of DNA methyltransferase-1 and induce DNA-hypomethylation. Induction of apoptosis is also clinically relevant, in particular...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Maria Teresa Voso, Valeria Santini, Emiliano Fabiani, Luana Fianchi, Marianna Criscuolo, Giulia Falconi, Francesco Guidi, Stefan Hohaus, Giuseppe Leone
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2014-04-01
Online Access:	https://haematologica.org/article/view/6990