Lysosomal TFEB‐TRPML1 Axis in Astrocytes Modulates Depressive‐like Behaviors

Abstract Lysosomes are important cellular structures for human health as centers for recycling, signaling, metabolism and stress adaptation. However, the potential role of lysosomes in stress‐related emotions has long been overlooked. Here, it is found that lysosomal morphology in astrocytes is alte...

Full description

Bibliographic Details

Published in:	Advanced Science
Main Authors:	Jia‐Wen Mo, Peng‐Li Kong, Li Ding, Jun Fan, Jing Ren, Cheng‐Lin Lu, Fang Guo, Liang‐Yu Chen, Ran Mo, Qiu‐Ling Zhong, You‐Lu Wen, Ting‐Ting Gu, Qian‐Wen Wang, Shu‐Ji Li, Ting Guo, Tian‐Ming Gao, Xiong Cao
Format:	Article
Language:	English
Published:	Wiley 2024-11-01
Subjects:	astrocytes ATP depressive‐like behaviors lysosomes mucolipin TRP channel 1 transcription factor EB
Online Access:	https://doi.org/10.1002/advs.202403389