The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy

CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration. We generated a novel monoclonal antibody agains...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Frontiers in Immunology
المؤلفون الرئيسيون:	Apoorvi Chaudhri, Xia Bu, Yunfei Wang, Michael Gomez, James A. Torchia, Ping Hua, Shao-Hsi Hung, Michael A. Davies, Gregory A. Lizee, Ulrich von Andrian, Patrick Hwu, Gordon J. Freeman
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2023-09-01
الموضوعات:	CX3CR1 CX3CL1 PD-1 tumor immune evasion cancer immunotherapy
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1237715/full