Muscle Contraction Regulates BDNF/TrkB Signaling to Modulate Synaptic Function through Presynaptic cPKCα and cPKCβI

The neurotrophin brain-derived neurotrophic factor (BDNF) acts via tropomyosin-related kinase B receptor (TrkB) to regulate synapse maintenance and function in the neuromuscular system. The potentiation of acetylcholine (ACh) release by BDNF requires TrkB phosphorylation and Protein Kinase C (PKC) a...

Full description

Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Erica Hurtado, Víctor Cilleros, Laura Nadal, Anna Simó, Teresa Obis, Neus Garcia, Manel M. Santafé, Marta Tomàs, Katherine Halievski, Cynthia L. Jordan, Maria A. Lanuza, Josep Tomàs
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-05-01
Subjects:	Bdnf-TrkB signaling neuromuscular junction PKC muscle contraction neurotransmission
Online Access:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00147/full