Biophysical and biochemical signatures of pancreatic stellate cell activation: insights into mechano-metabolic signalling from atomic force microscopy and Raman spectroscopy

Abstract Background Pancreatic fibrosis is a key pathological feature of chronic pancreatitis and pancreatic cancer, driven by the persistent activation of pancreatic stellate cells. These cells, normally quiescent, undergo profound phenotypic changes in response to environmental cues, yet the inter...

Full description

Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Jacek J. Litewka, Monika A. Jakubowska, Marta Targosz-Korecka, Ewelina Wiercigroch, Jakub Dybas, Natalia Cisak, Zbigniew Madeja, Pawel E. Ferdek
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Pancreatic stellate cells Fibrosis Lipid metabolism Cytoskeletal remodelling Mechanical properties Raman spectroscopy
Online Access:	https://doi.org/10.1186/s12964-025-02354-1