SARS-CoV-2 Delta Variant N Gene Mutations Reduce Sensitivity to the TaqPath COVID-19 Multiplex Molecular Diagnostic Assay

As the SARS-CoV-2 virus evolves, mutations may result in diminished sensitivity to qRT-PCR diagnostic assays. We investigated four polymorphisms circulating in the SARS-CoV-2 Delta lineage that result in <i>N</i> gene target failure (NGTF) on the TaqPath COVID-19 Combo Kit. These mutatio...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Steven C. Holland, Ajeet Bains, LaRinda A. Holland, Matthew F. Smith, Regan A. Sullins, Nicholas J. Mellor, Alexis W. Thomas, Nathaniel Johnson, Vel Murugan, Efrem S. Lim
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Subjects:	SARS-CoV-2 COVID-19 delta variant N gene dropout qRT-PCR
Online Access:	https://www.mdpi.com/1999-4915/14/6/1316