PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer’s disease

Disrupted tau proteostasis and transneuronal spread is a pathological hallmark of Alzheimer’s disease. Neurodegenerative diseases remain an unmet medical need and novel disease modifying therapeutics are paramount. Our objective was to develop a mechanistic mathematical model to enhance our understa...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Peter Bloomingdale, Daniela Bumbaca-Yadav, Jonathan Sugam, Steve Grauer, Brad Smith, Svetlana Antonenko, Michael Judo, Glareh Azadi, Ka Lai Yee
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	PBPK QSP antibody tau Alzheimer’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.867457/full