All-in-one IQ toggle switches with high versatilities for fine-tuning of transgene expression in mammalian cells and tissues

The transgene toggling device is recognized as a powerful tool for gene- and cell-based biological research and precision medicine. However, many of these devices often operate in binary mode, exhibit unacceptable leakiness, suffer from transgene silencing, show cytotoxicity, and have low potency. H...

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Bibliographic Details

Published in:	Molecular Therapy: Methods & Clinical Development
Main Authors:	Jeongkwan Hong, Kyung-Cheol Sohn, Hye-Won Park, Hyoeun Jeon, Eunjin Ju, Jae-Geun Lee, Jeong-Soo Lee, Jaerang Rho, Gang Min Hur, Hyunju Ro
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	transgene toggling SIQ tebufenozide cumate SIQmate adenovirus
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050124000184