A Pipeline for Natural Small Molecule Inhibitors of Endoplasmic Reticulum Stress

The homeostasis of eukaryotic cells is inseverable of that of the endoplasmic reticulum (ER). The main function of this organelle is the synthesis and folding of a significant portion of cellular proteins, while it is also the major calcium reservoir of the cell. Upon unresolved ER stress, a set of...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Daniela Correia da Silva, Patrícia Valentão, Paula B. Andrade, David M. Pereira
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Subjects:	endoplasmic reticulum stress unfolded protein response drug discovery neurodegeneration natural products
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.956154/full