Mapping of catecholaminergic denervation, neurodegeneration, and inflammation in 6-OHDA-treated Parkinson’s disease mice

Abstract Efforts to develop disease-modifying treatments for Parkinson’s disease (PD) have been hindered by the lack of animal models replicating all hallmarks of PD and the insufficient attention to extra-nigrostriatal regions pathologically critical for the prodromal appearance of non-motor sympto...

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Bibliographic Details

Published in:	npj Parkinson's Disease
Main Authors:	Matteo Santoro, Rachel K. Lam, Sarah E. Blumenfeld, Weiqi Tan, Peter Ciari, Emily K. Chu, Nay L. Saw, Daniel Ryskamp Rijsketic, Jennifer S. Lin, Boris D. Heifets, Mehrdad Shamloo
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Online Access:	https://doi.org/10.1038/s41531-025-00872-w