Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease

Abstract Background Blood–brain barrier (BBB) dysfunction is supposed to be an early event in the development of Alzheimer’s disease (AD). This study aimed to investigate the relationship between BBB alterations and AD progression in terms of amyloid-β peptide (Aβ) accumulation in the brains of huma...

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出版年:	Fluids and Barriers of the CNS
主要な著者:	Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda, Takashi Saito, Takaomi Saido, Sumio Ohtsuki
フォーマット:	論文
言語:	英語
出版事項:	BMC 2023-09-01
主題:	Alzheimer’s disease Amyloid-β peptide Blood–brain barrier Apolipoprotein Basement membrane Proteome analysis
オンライン･アクセス:	https://doi.org/10.1186/s12987-023-00466-9