Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway

Objective: To investigate the therapeutic potential of dimethyl fumarate (DMF) in improving erectile function of bilateral cavernous nerve injury (BCNI) rats, along with elucidating its underlying mechanisms. Methods: A BCNI rat model was established by clamping bilateral cavernous nerve (CN). DMF w...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Guoda Song, Jiaxin Wang, Jihong Liu, Yajun Ruan
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Dimethyl fumarate Erectile dysfunction Cavernous nerve injury Oxidative stress Pyroptosis Nrf2/HO-1
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231723003397