Introduction and expression of PIK3CA E545K in a papillary thyroid cancer BRAF V600E cell line leads to a dedifferentiated aggressive phenotype

Abstract Anaplastic thyroid cancer (ATC) is a rare, aggressive form of undifferentiated thyroid cancer, which exhibits rapid progression and is almost universally fatal. At least a subset of ATC is thought to arise from pre-existing well-differentiated thyroid cancer, most frequently papillary thyro...

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Bibliographic Details

Published in:	Journal of Otolaryngology - Head and Neck Surgery
Main Authors:	Nicole Pinto, Kara M. Ruicci, Mohammed Imran Khan, Mushfiq Hassan Shaikh, Yu Fan Peter Zeng, John Yoo, Kevin Fung, S. Danielle MacNeil, Adrian Mendez, Joe S. Mymryk, John W. Barrett, Paul C. Boutros, Anthony C. Nichols
Format:	Article
Language:	English
Published:	SAGE Publishing 2022-02-01
Subjects:	Papillary thyroid cancer Anaplastic thyroid cancer Disease progression Dedifferentiation
Online Access:	https://doi.org/10.1186/s40463-022-00558-w