Activation of AMPK/mTOR-Driven Autophagy and Suppression of the HMGB1/TLR4 Pathway with Pentoxifylline Attenuates Doxorubicin-Induced Hepatic Injury in Rats

Despite being an effective chemotherapeutic agent, the clinical use of doxorubicin (DOX) is limited by several organ toxicities including hepatic injury. Pentoxifylline (PTX) is a methylxanthine derivative with marked anti-inflammatory and anti-apoptotic features. It is unknown, however, whether PTX...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Hany H. Arab, Ahmed H. Eid, Shuruq E. Alsufyani, Ahmed M. Ashour, Alwaleed M. Alnefaie, Nasser M. Alsharif, Abdullah M. Alshehri, Abdulmajeed A. Almalawi, Abdulmajeed A. Alsowat, Hayat A. Abd El Aal, Eman S. G. Hassan, Wessam H. Elesawy, Alzahraa A. Elhemiely
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	pentoxifylline doxorubicin hepatotoxicity autophagy AMPK HMGB1
Online Access:	https://www.mdpi.com/1424-8247/17/6/681