Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies

Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage. The influence of the linkages on the self-assembly, in vivo fate and ant...

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Bibliographic Details

Published in:	Asian Journal of Pharmaceutical Sciences
Main Authors:	Lingxiao Li, Shiyi Zuo, Fudan Dong, Tian Liu, Yanlin Gao, Yinxian Yang, Xin Wang, Jin Sun, Bingjun Sun, Zhonggui He
Format:	Article
Language:	English
Published:	Elsevier 2021-05-01
Subjects:	Diselenide bond Homodimeric prodrug Docetaxel Self-assembly Redox responsive
Online Access:	http://www.sciencedirect.com/science/article/pii/S1818087621000155