Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

Abstract Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical and clinical results, particularly in hematological malignancies. Ectopically expressed chimeric antigen receptors (CARs) reprogram immune ce...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Journal of Translational Medicine
المؤلفون الرئيسيون:	Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Juli Rodriguez Bago, Roman Hájek, Matouš Hrdinka
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2023-03-01
الموضوعات:	Chimeric antigen receptor CAR Cancer Immunotherapy T cell Synthetic
الوصول للمادة أونلاين:	https://doi.org/10.1186/s12967-023-04041-6