Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

With the continual evolution of new strains of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that are more virulent, transmissible, and able to evade current vaccines, there is an urgent need for effective anti-viral drugs. The SARS-CoV-2 main protease (Mpro) is a leading target for d...

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Bibliographic Details

Published in:	eLife
Main Authors:	Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Celia A Schiffer, Stephanie A Moquin, Dustin Dovala, Daniel NA Bolon
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2022-06-01
Subjects:	Mpro SARS-CoV-2 deep mutational scanning main protease
Online Access:	https://elifesciences.org/articles/77433