Alternative Lengthening of Telomeres: A Prognostic Paradox in Cancer

Telomere maintenance enables unlimited cell proliferation by counteracting telomere erosion. While the majority of tumors activate telomerase, a significant subset—approximately 10–15%—utilizes alternative lengthening of telomeres (ALT), a recombination-based mechanism. ALT-positive cancers are clas...

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Bibliographic Details

Published in:	Cells
Main Author:	Ji-Yong Sung
Format:	Article
Language:	English
Published:	MDPI AG 2025-10-01
Subjects:	alternative lengthening of telomeres (ALT) telomere maintenance mechanisms ATRX/DAXX mutations genomic instability DNA damage response (DDR) glioblastoma (GBM)
Online Access:	https://www.mdpi.com/2073-4409/14/20/1613