Administration of L-Type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential

We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or immunohistochemistry. Protein misfolding cyclic amplifica...

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Bibliographic Details

Published in:	Emerging Infectious Diseases
Main Authors:	Morikazu Imamura, Ken’ichi Hagiwara, Minoru Tobiume, Minako Ohno, Hiromi Iguchi, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi, Hiroaki Shibata, Fumiko Ono
Format:	Article
Language:	English
Published:	Centers for Disease Control and Prevention 2025-05-01
Subjects:	prions zoonoses oral transmission bovine spongiform encephalopathy cynomolgus macaques L-Type bovine spongiform encephalopathy
Online Access:	https://wwwnc.cdc.gov/eid/article/31/5/24-1257_article