Host parameters and mode of infection influence outcome in SARS-CoV-2-infected hamsters

Summary: The golden hamster model of SARS-CoV-2 infection recapitulates key characteristics of COVID-19. In this work we examined the influence of the route of exposure, sex, and age on SARS-CoV-2 pathogenesis in hamsters. We report that delivery of SARS-CoV-2 by a low- versus high-volume intranasal...

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Bibliographic Details

Published in:	iScience
Main Authors:	Bryan D. Griffin, Bryce M. Warner, Mable Chan, Emelissa Valcourt, Nikesh Tailor, Logan Banadyga, Anders Leung, Shihua He, Amrit S. Boese, Jonathan Audet, Wenguang Cao, Estella Moffat, Lauren Garnett, Kevin Tierney, Kaylie N. Tran, Alixandra Albietz, Kathy Manguiat, Geoff Soule, Alexander Bello, Robert Vendramelli, Jessica Lin, Yvon Deschambault, Wenjun Zhu, Heidi Wood, Samira Mubareka, David Safronetz, James E. Strong, Carissa Embury-Hyatt, Darwyn Kobasa
Format:	Article
Language:	English
Published:	Elsevier 2021-12-01
Subjects:	Cellular physiology Microbiology Virology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221015017