A drug response prediction method for single-cell tumors combining attention networks and transfer learning

IntroductionAccurately predicting tumor cell line responses to therapeutic drugs is essential for personalized cancer treatment. Current methods using bulk cell data fail to fully capture tumor heterogeneity and the complex mechanisms underlying treatment responses.MethodsThis study introduces a nov...

Full description

Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	BingWei Zhou, SiLin Sun, ShengZheng Liu, HaiXia Long, YuChun Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	tumor drug response prediction attention mechanism transfer learning bulk RNA sequencing single-cell RNA sequencing
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1631898/full