Mechanisms for fibrate lipid-lowering drugs in enhancing bladder cancer immunotherapy by inhibiting CD276 expression

Abstract Objective This study aimed to investigate the growth-inhibitory effects of fibrate lipid-lowering drugs on bladder cancer cells and their underlying mechanisms, with a focus on exploring how fenofibrate (FNF) exerts antitumor effects by regulating mitochondrial function, the AMPK/mTOR signa...

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Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Cheng Li, Jiahao Liu, Long Wang, Wei Xiong
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Bladder cancer Fibrate lipid-lowering drugs Fenofibrate CD276 Immunotherapy
Online Access:	https://doi.org/10.1186/s12885-025-14855-w