Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia

Abstract Preeclampsia results from placental insufficiency and causes maternal endothelial dysfunction and multi-organ damage. Our in-silico analysis identified Cystatin 6 (CST6), a cysteine protease inhibitor, as located on the placental surface where it might be released into maternal circulation....

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Stefan M. Botha, Lucy A. Bartho, Sunhild Hartmann, Ping Cannon, Anna Nguyen, Tuong-Vi Nguyen, Natasha Pritchard, Ralf Dechend, Olivia Nonn, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Subjects:	Cystatin 6 CST6 Legumain LGMN Pregnancy Preeclampsia
Online Access:	https://doi.org/10.1038/s41598-025-96823-9