Identification of Potential Multitarget Compounds against Alzheimer’s Disease through Pharmacophore-Based Virtual Screening

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive loss of cognitive functions, and it is the most prevalent type of dementia worldwide, accounting for 60 to 70% of cases. The pathogenesis of AD seems to involve three main factors: deficiency in cholinergic transmis...

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出版年:	Pharmaceuticals
主要な著者:	Géssica Oliveira Mendes, Moysés Fagundes de Araújo Neto, Deyse Brito Barbosa, Mayra Ramos do Bomfim, Lorena Silva Matos Andrade, Paulo Batista de Carvalho, Tiago Alves de Oliveira, Daniel Luciano Falkoski, Eduardo Habib Bechelane Maia, Marcelo Siqueira Valle, Laila Cristina Moreira Damázio, Alisson Marques da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leite
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2023-11-01
主題:	Alzheimer’s disease human acetylcholinesterase human butyrylcholinesterase human beta-secretase 1
オンライン･アクセス:	https://www.mdpi.com/1424-8247/16/12/1645