Opioid growth factor receptor overexpression exerts anti-hepatocellular carcinoma effects by activating P16 and P21 to inhibit proliferation and migration of HepG2 cells

INTRODUCTION: Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer death worldwide [19]. Opioid growth factor (OGF) has been shown to exhibit antitumour potential, binding to OGF receptor (OGFr). Naltrexone (NTX), an OGFr antagonist, is consid...

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Bibliographic Details

Published in:	Folia Histochemica et Cytobiologica
Main Authors:	Zhezhu Jin, Yongjun Jin
Format:	Article
Language:	English
Published:	Via Medica 2024-12-01
Subjects:	hepatocellular carcinoma OGFr cell proliferation cell migration P21 P16
Online Access:	https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/101622