Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth

Abstract The eukaryotic Glucose Induced Degradation/C-Terminal to LisH (GID/CTLH) complex is a highly conserved E3 ubiquitin ligase involved in a broad range of biological processes. However, a role of this complex in host anti-microbial defenses has not been described. We exploited Mycobacterium tu...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Nelson V. Simwela, Luana Johnston, Paulina Pavinski Bitar, Eleni Jaecklein, Craig Altier, Christopher M. Sassetti, David G. Russell
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Online Access:	https://doi.org/10.1038/s41467-024-53637-z