Bifunctional Role of Fe(II)/2OG-Dependent TET Family 5-Methylcytosine Dioxygenases and ALKBH2,3 in Modified Cytosine Demethylation

Three forms of methylated cytosines are present in the eukaryotic genome: 3-methylcytosine, 4-methylcytosine and 5-methylcytosine. 3-methylcytosines create methyl lesions, which impair local DNA function and flexibility, resulting in replication and transcription error. On the other hand, 5-methylcy...

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Bibliographic Details

Published in:	BioChem
Main Author:	Aninda Sundar Dey
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Subjects:	modified cytosine demethylation ALKBH direct demethylation TET oxidative demethylation functional flexibility
Online Access:	https://www.mdpi.com/2673-6411/2/3/12