Bifunctional Role of Fe(II)/2OG-Dependent TET Family 5-Methylcytosine Dioxygenases and ALKBH2,3 in Modified Cytosine Demethylation

Three forms of methylated cytosines are present in the eukaryotic genome: 3-methylcytosine, 4-methylcytosine and 5-methylcytosine. 3-methylcytosines create methyl lesions, which impair local DNA function and flexibility, resulting in replication and transcription error. On the other hand, 5-methylcy...

書誌詳細
出版年:	BioChem
第一著者:	Aninda Sundar Dey
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2022-07-01
主題:	modified cytosine demethylation ALKBH direct demethylation TET oxidative demethylation functional flexibility
オンライン･アクセス:	https://www.mdpi.com/2673-6411/2/3/12

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