A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites

Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug targets for hypnozoites, we screened the Repurposing, Focused R...

Full description

Bibliographic Details
Published in:eLife
Main Authors: Steven P Maher, Malina A Bakowski, Amélie Vantaux, Erika L Flannery, Chiara Andolina, Mohit Gupta, Yevgeniya Antonova-Koch, Magdalena Argomaniz, Monica Cabrera-Mora, Brice Campo, Alexander T Chao, Arnab K Chatterjee, Wayne T Cheng, Vorada Chuenchob, Caitlin A Cooper, Karissa Cottier, Mary R Galinski, Anke Harupa-Chung, Hana Ji, Sean B Joseph, Todd Lenz, Stefano Lonardi, Jessica Matheson, Sebastian A Mikolajczak, Timothy Moeller, Agnes Orban, Vivian Padín-Irizarry, Kastin Pan, Julie Péneau, Jacques Prudhomme, Camille Roesch, Anthony Ruberto, Saniya S Sabnis, Celia L Saney, Jetsumon Sattabongkot, Saleh Sereshki, Sangrawee Suriyakan, Ratawan Ubalee, Yinsheng Wang, Praphan Wasisakun, Jiekai Yin, Jean Popovici, Case W McNamara, Chester Joyner, François H Nosten, Benoît Witkowski, Karine G Le Roch, Dennis E Kyle
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-09-01
Subjects:
Plasmodium vivax
Plasmodium cynomolgi
hypnozoites
primary hepatocytes
malaria
DNA methylation
Online Access:https://elifesciences.org/articles/98221

Internet

https://elifesciences.org/articles/98221

Similar Items