Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer

Abstract TGF-β ligands suppress growth yet can paradoxically and potently promote cancer invasion and metastasis depending on downstream pathway mutational context, such as loss of Mothers against decapentaplegic homolog 4 (Smad4). Here, we characterised phenotypes and associated gene expression sig...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Mirvat Surakhy, Julia Matheson, David J. Barnes, Emma J. Carter, Jennifer Hughes, Claudia Bühnemann, Sabina Sanegre, Hans Morreau, Paul Metz, Charlotte J. Imianowski, Andrew Bassim Hassan
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Subjects:	Smad4 Apc Intestine Adenoma TGF-β1 Id1
Online Access:	https://doi.org/10.1038/s41598-025-00908-4