Constitutive expression of spliced X-box binding protein 1 inhibits dentin formation in mice

Upon endoplasmic reticulum (ER) stress, inositol-requiring enzyme 1 (IRE1) is activated, which subsequently converts an unspliced X-box binding protein 1 (XBP1U) mRNA to a spliced mRNA that encodes a potent XBP1S transcription factor. XBP1S is essential for relieving ER stress and secretory cell dif...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Qian Xu, Jiahe Li, Hua Zhang, Suzhen Wang, Chunlin Qin, Yongbo Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	X-box binding protein 1 (XBP1) tooth development odontoblast cell differentiation dentin dentinogenesis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2023.1319954/full