Emerging role of ubiquitination/deubiquitination modification of PD-1/PD-L1 in cancer immunotherapy

As members of the immune checkpoint family, PD-1 and its ligand PD-L1 play critical roles in maintaining the balance between autoimmunity and tolerance. The interaction of PD-1/PD-L1 is also involved in tumor evasion inside the tumor microenvironment, caused by reduced T cell activation, proliferati...

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Bibliographic Details

Published in:	Genes and Diseases
Main Authors:	Peng Ding, Zhiqiang Ma, Yizeng Fan, Yingtong Feng, Changjian Shao, Minghong Pan, Yimeng Zhang, Di Huang, Jing Han, Yi Hu, Xiaolong Yan
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2023-05-01
Subjects:	Cancer Deubiquitination Immunotherapy PD-1 PD-L1 Ubiquitination
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304222000320