Human stem cell–derived neurons and astrocytes to detect novel auto-reactive IgG response in immune-mediated neurological diseases

Background and objectivesUp to 46% of patients with presumed autoimmune limbic encephalitis are seronegative for all currently known central nervous system (CNS) antigens. We developed a cell-based assay (CBA) to screen for novel neural antibodies in serum and cerebrospinal fluid (CSF) using neurons...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Amandine Mathias, Sylvain Perriot, Samuel Jones, Mathieu Canales, Raphaël Bernard-Valnet, Marie Gimenez, Nathan Torcida, Larise Oberholster, Andreas F. Hottinger, Anastasia Zekeridou, Marie Theaudin, Caroline Pot, Renaud Du Pasquier
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	auto-antibody human-induced pluripotent stem cells neural cells NMO seronegative auto-immune encephalitis/paraneoplastic syndrome immune-mediated neurological syndromes
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1419712/full