Diversity for endoribonuclease nsp15-mediated regulation of alpha-coronavirus propagation and virulence

ABSTRACT Endoribonuclease non-structural protein 15 (nsp15) (EndoU) is conserved among coronaviruses (CoVs) and is crucial for viral replication, evasion of the innate immune system, and virulence. EndoU-deficient CoVs can activate the interferon (IFN) response and attenuate their virulence, and nsp...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Yunfei Xie, Chener Chen, Ding Zhang, Zhe Jiao, Yixi Chen, Gang Wang, Yubei Tan, Wanpo Zhang, Shaobo Xiao, Guiqing Peng, Yuejun Shi
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-12-01
Subjects:	alpha-coronavirus endoribonuclease nsp15 propagation virulence
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.02209-23