A Distinctive Metabolomics Pattern Associated with the Administration of Combined Sacubitril/Valsartan to Healthy Subjects: A Kinetic Approach

<b>Background/Objective:</b> Sacubitril/Valsartan are a combination drug approved for heart failure treatment, known to enhance natriuretic peptide activity and inhibit the renin–angiotensin–aldosterone system (RAAS). While its clinical efficacy is well-established, its broader impact on...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Randh AlAhmari, Hana M. A. Fakhoury, Reem AlMalki, Hatouf H. Sukkarieh, Lina Dahabiyeh, Tawfiq Arafat, Anas M. Abdel Rahman
Format:	Article
Language:	English
Published:	MDPI AG 2025-08-01
Subjects:	Sacubitril/Valsartan metabolomics LC-QToF HRMS pyrimidine metabolism pharmacokinetics uridine triphosphate
Online Access:	https://www.mdpi.com/1424-8247/18/9/1264