Cleistanthin A derivative disrupts autophagy and suppresses head and neck squamous cell carcinoma progression via targeted vacuolar ATPase

Abstract Head and neck squamous cell carcinoma (HNSCC) present a significant challenge due to its heterogeneity and limited treatment options, often resulting in severe side effects and poor survival rates with conventional chemoradiotherapy. Here, we investigated the anticancer activity of halogena...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Anongnat Wongpan, Wittaya Panvongsa, Sucheewin Krobthong, Bodee Nutho, Phongthon Kanjanasirirat, Kedchin Jearawuttanakul, Tanawadee Khumpanied, Sureeporn Phlaetita, Napason Chabang, Bamroong Munyoo, Patoomratana Tuchinda, Marisa Ponpuak, Suparerk Borwornpinyo, Arthit Chairoungdua
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Subjects:	Head and neck squamous cell carcinoma Cleistanthin A derivative Vacuolar ATPase Autophagy Anticancer
Online Access:	https://doi.org/10.1038/s41598-024-73186-1