Persistent Activation of Sphingosine‐1‐Phosphate Receptor 1 by Phytosphingosine‐3,4‐Cyclic Phosphate Ameliorates Sepsis by Inhibiting Hyperinflammation and Vascular Hyperpermeability

ABSTRACT Sepsis is a life‐threatening disease characterized by multiorgan dysfunction caused by an abnormal immune response to microbial infection. Sphingosine‐1‐phosphate (S1P) levels are significantly lower in patients with sepsis and are negatively correlated with the severity of sepsis. However,...

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Bibliographic Details

Published in:	MedComm
Main Authors:	Suhong Duan, Seung‐Gook Kim, Jiaying Bao, Hyung‐Jin Lim, Joon Woo Kim, Sung‐Il Yoon, Young Jun Park, Sanguk Yun, Kye‐Seong Kim, Hwa‐Ryung Song, Myeong Jun Choi, Myung‐Kwan Han
Format:	Article
Language:	English
Published:	Wiley 2025-06-01
Subjects:	cecal ligation and puncture phytosphingosine‐3,4‐cyclic phosphate sepsis sirtuin 1 (SIRT1) sphingosine‐1‐phosphate sphingosine‐1‐phosphate receptor 1
Online Access:	https://doi.org/10.1002/mco2.70238