Characterization of pSer129-αSyn Pathology and Neurofilament Light-Chain Release across In Vivo, Ex Vivo, and In Vitro Models of Pre-Formed-Fibril-Induced αSyn Aggregation

Protein aggregation is a predominant feature of many neurodegenerative diseases, including synucleinopathies, which are characterized by cellular inclusions containing α-Synuclein (αSyn) phosphorylated at serine 129 (pSer129). In the present study, we characterized the development of αSyn pre-formed...

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Bibliographic Details

Published in:	Cells
Main Authors:	Maja L. Hansen, Malene Ambjørn, Mikkel N. Harndahl, Tau Benned-Jensen, Karina Fog, Kaare Bjerregaard-Andersen, Florence Sotty
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Subjects:	alpha-synuclein pre-formed fibrils protein aggregation neurofilament light chain biomarkers neurodegeneration
Online Access:	https://www.mdpi.com/2073-4409/13/3/253