Use of the 2D <sup>1</sup>H-<sup>13</sup>C HSQC NMR Methyl Region to Evaluate the Higher Order Structural Integrity of Biopharmaceuticals

The higher-order structure (HOS) of protein therapeutics is directly related to the function and represents a critical quality attribute. Currently, the HOS of protein therapeutics is characterized by methods with low to medium structural resolution, such as Fourier transform infrared (FTIR), circul...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Molecules
المؤلفون الرئيسيون: Tsang-Lin Hwang, Dipanwita Batabyal, Nicholas Knutson, Mats Wikström
التنسيق: مقال
اللغة:الإنجليزية
منشور في: MDPI AG 2021-05-01
الموضوعات:
higher-order structure
tertiary structure
fluorescence
circular dichroism
NMR
HOS by NMR
الوصول للمادة أونلاين:https://www.mdpi.com/1420-3049/26/9/2714

الانترنت

https://www.mdpi.com/1420-3049/26/9/2714

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