In vitro and in vivo evaluation of thapsigargin as an antiviral agent against transmissible gastroenteritis virus

Abstract Swine enteric coronaviruses (SeCoVs) pose a significant threat to the global pig industry, but no effective drugs are available for treatment. Previous research has demonstrated that thapsigargin (TG), an ER stress inducer, has broad-spectrum antiviral effects on human coronaviruses. In thi...

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Bibliographic Details

Published in:	Veterinary Research
Main Authors:	Yang Li, Yuanyuan Liu, Yunhang Zhang, Chen Tan, Yifei Cai, Yue Zhang, Jianing Chen, Yuguang Fu, Guangliang Liu
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	thapsigargin intestinal organoids ERS antiviral drug TGEV
Online Access:	https://doi.org/10.1186/s13567-024-01359-x