FLT3L combined with GM-CSF induced dendritic cells drive broad tumor-specific CD8+ T cell responses and remodel the tumor microenvironment to enhance anti-tumor efficacy

BackgroundDendritic cells (DCs) play a crucial role in anti-tumor immunity by capturing, processing, and presenting tumor antigens to T cells, making DC-based immunotherapy a promising approach for cancer treatment. However, the most commonly used clinical strategy still relies on inducing DCs in vi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Qian Zheng, Jiajie Zhang, He Sui, Yu Sun, Ningning Lv, Lin Liu, Ming Qu, Jiateng Tan, Bin Zhang, Zhanhao Mo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	dendritic cells DCs FLT3L GM-CSF cDC1 anti-tumor efficacy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1649891/full