Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties

Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral and cellular NEC-associated factors that jointly exert nucle...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Manfred Marschall, Sigrun Häge, Marcus Conrad, Sewar Alkhashrom, Jintawee Kicuntod, Johannes Schweininger, Mark Kriegel, Josephine Lösing, Julia Tillmanns, Frank Neipel, Jutta Eichler, Yves A. Muller, Heinrich Sticht
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Subjects:	human cytomegalovirus (HCMV) nuclear egress complex (NEC) core NEC crystal structures α-, β-, γ-herpesviral NECs sequence coevolution highly conserved structures
Online Access:	https://www.mdpi.com/1999-4915/12/6/683