From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer

Acetyl CoA acetyltransferase 1 (ACAT1), a mitochondrial enzyme, is mainly involved in the formation and decomposition of ketones, isoleucine, and fatty acids. Previous clinical studies showed that mutations in the ACAT1 gene lead to ketoacidosis, Notably the role of ACAT1 in human cancer’ pathogenes...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Wei He, Yanfang Li, Song-Bai Liu, Ying Chang, Shiyuan Han, Xingyu Han, Zixin Ma, Hesham M. Amin, Yao-Hua Song, Jin Zhou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	gastric cancer ACAT1 tumor stem cells EMT mitochondrial enzyme
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1449525/full