BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, dominantly inherited neurodegenerative disease caused by the expanded polyQ tract in the protein ATAXIN1 (ATXN1) and characterized by progressive motor and cognitive impairments. There are no disease-modifying treatments or cures for SCA1. Brai...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Juao-Guilherme Rosa, Katherine Hamel, Alyssa Soles, Carrie Sheeler, Ella Borgenheimer, Stephen Gilliat, Kaelin Sbrocco, Ferris Ghanoum, Hillary P. Handler, Colleen Forster, Orion Rainwater, Marija Cvetanovic
Format:	Article
Language:	English
Published:	Elsevier 2023-03-01
Subjects:	SCA1 BDNF Neurodegeneration Brain region specific Motor deficits Cognition
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996123000372