Clinical utility of repeated IgH gene rearrangement testing for the diagnosis and surveillance of gastric MALT lymphoma

Abstract Gastric MALT lymphoma diagnosis relies on histopathological findings and immunoglobulin H gene (IgHr) rearrangement testing, which reflects monoclonal immunoglobulin proliferation. This study aimed to clarify the role of IgHr in the diagnosis, treatment prediction, and surveillance of gastr...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Hidehiko Takigawa, Yuki Kitadai, Daisuke Shimizu, Misa Ariyoshi, Takeshi Takasago, Akiyoshi Tsuboi, Hidenori Tanaka, Ken Yamashita, Yuichi Hiyama, Yoshihiro Kishida, Yuji Urabe, Akira Ishikawa, Ryo Yuge, Toshio Kuwai, Shiro Oka
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Subjects:	IgH rearrangement Pathological diagnosis Gastric MALT lymphoma Eradication therapy Surveillance Prediction
Online Access:	https://doi.org/10.1038/s41598-025-16512-5