Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins

Abstract Background Metazoans inherited genes from unicellular ancestors that perform essential biological processes such as cell division, metabolism, and protein translation. Multicellularity requires careful control and coordination of these unicellular genes to maintain tissue integrity and home...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Anna S. Trigos, Felicia Bongiovanni, Yangyi Zhang, Maia Zethoven, Richard Tothill, Richard Pearson, Anthony T. Papenfuss, David L. Goode
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Subjects:	Cancer Gene expression Expression modules Atavism Evolution
Online Access:	https://doi.org/10.1186/s13059-024-03247-1