Insulin‐like growth factor‐1 receptor regulates repair of ultraviolet B‐induced DNA damage in human keratinocytes in vivo

The activation status of the insulin‐like growth factor‐1 receptor (IGF‐1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo. Geriatric skin is deficient in IGF‐1 expression resulting in an aberrant IGF‐1R‐dependent UVB response which contri...

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Bibliographic Details

Published in:	Molecular Oncology
Main Authors:	Mathew M. Loesch, Ann E. Collier, David H. Southern, Rachel E. Ward, Sunil S. Tholpady, Davina A. Lewis, Jeffrey B. Travers, Dan F. Spandau
Format:	Article
Language:	English
Published:	Wiley 2016-10-01
Subjects:	IGF-1R NER Keratinocyte UVB Xenograft
Online Access:	https://doi.org/10.1016/j.molonc.2016.06.002