Maternal exposure to dibutyl phthalate (DBP) impairs angiogenesis and AR signalling pathway through suppression of TGFB1I1 in hypospadias offspring

Early exposure to dibutyl phthalate (DBP) can cause hypospadias in newborn foetuses. However, the underlying molecular mechanism is not well defined. Aberrant angiogenesis is associated with various dysplasias including urogenital deficits. In vivo and in vitro angiogenesis assays showed reduced ang...

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Bibliographic Details

Published in:	Ecotoxicology and Environmental Safety
Main Authors:	Lei Wu, Fei Shi, Yongqing Zhang, Xinyu Xu, Zhiwen Xie, Shan Hua, Shujie Xia, Juntao Jiang
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Dibutyl phthalate Hypospadias TGFB1I1 AR Angiogenesis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0147651324000162